Glupride Multi is a unique vitamin/herbal formula designed to promote healthy glucose levels already within the normal range.*
Vitamins and minerals are essential for the normal metabolism of our body. Endocrinologists are expert in the field of metabolism. They understand which vitamins and minerals are beneficial for the normal functioning of the body.
For example, most multivitamins contain Potassium. Most diabetic patients are on an Ace-inhibitor drug (such as Altace, Vasotec, Accupril, Zestril, etc.) or an ARB drug (such as Cozaar, Avapro, Atacand, Benicar, Diovan, etc.) These drugs can increase the potassium level in blood, which can be life-threatening. Potassium in a multi-vitamin can further increase this potassium level. Patients usually don't tell their physicians they're taking vitamins that contain potassium. When a physician encounters a patient with a high potassium level, they often stop the Ace-inhibitor or ARB drug, inadvertently depriving the patient of the beneficial effects of these helpful drugs. In contrast, all they had to do was to stop the multivitamin that contained potassium and advise the patient on a low potassium diet.
Another problem: Most multivitamins contain vitamin K which may increase the amount of clotting factors in the body. Most diabetics have underlying insulin resistance, which increases the level of many clotting factors, which in turn increases risk for clot formation and acute vascular events, such as a heart attack and stroke. An extra dose of Vitamin K in multivitamin preparations may actually be harmful in these patients. It's like adding fuel to the fire. Also, many of these patients are on Coumadin. Vitamin K interferes with Coumadin and it becomes extremely difficult to find the right dose of Coumadin in these patients.
Many multivitamins also contain high dose of vitamin E. Most recent studies show that Vitamin E in large doses may not be cardio-protective and may even be harmful. However, most multi-vitamins continue to include mega doses of Vitamin E.
Another problem: Most multivitamins also contain calcium and iron, both of which can interfere with the absorption of thyroid hormone, which many diabetic patients take.
Glupride-Multi does not contain Potassium, Vitamin K, Calcium or Iron. It contains small amounts of Vitamin E to meet the daily requirements.
Glupride Multi contains 21 different vitamins, minerals and herbs. It contains Alpha-Lipoic Acid, Chromium Picolinate, Cinnamon and Coenzyme Q 10 in addition to B vitamins, Vitamin A, Vitamin E, Vitamin C and essential minerals including Selenium, Zinc, Vanadium and Magnesium.
Alpha-lipoic acid is normally produced in cells in small amounts and helps in the normal metabolism of glucose. Alpha-lipoic acid functions as a strong anti-oxidant in the body (1, 2).*
The cells of diabetic patients are under a tremendous amount of daily oxidative stress. That's why it makes sense to use Alpha-Lipoic acid as a dietary supplement in people with diabetes.*
A number of scientific studies have shown that alpha-lipoic acid promotes normal insulin sensitivity and thus may promote health in diabetic patients (2).*
Several studies have also shown alpha-lipoic acid to be helpful in promoting nerve health in humans (3).*
In Germany, Alpha-lipoic acid has been used for over 30 years. The amount of Alpha-lipoic acid is important! In these studies, the amount used was 600-1800 mg per day. Some multivitamins add a tiny amount of Alpha-lipoic acid, such as 100 mg per day. In contrast, we use a dose of 600 mg per day in Glupride Multi.
Chromium picolinate is required for the normal metabolism of glucose.* Several studies have shown beneficial effects of chromium supplementation in promoting health of diabetic patients.*
One large clinical trial tested chromium picolinate in 833 Type 2 diabetic patients and found a significant improvement in their blood glucose values (4).
The amount of chromium picolinate is also important. Many multivitamins contain only a small amount of chromium picolinate. In contrast, we use a large dose of 600 mcg per day as was used in these clinical studies.*
Physicians have long been intrigued by the beneficial effects of cinnamon.
In December 2003, an excellent scientific study was published in Diabetes Care, (5) in which cinnamon powder was used in 60 patients with Type 2 diabetes. Three daily doses, 1 gram, 3 grams and 6 grams were used. There was a decrease in blood glucose by 18-29%. Serum triglycerides also decreased by 23-30%. Patients consuming 6 grams of cinnamon powder per day appeared to have achieved results earlier (at 20 days), but at 40 days, all doses had the same efficacy in lowering blood glucose and triglycerides level.*
Coenzyme Q10 is a strong antioxidant*. It may help to improve diastolic dysfunction of the heart in patients with hypertension, which is so commonly present in patients with diabetes*.
Statin drugs such as Lipitor (atorvastatin), Zocor (simvastatin), Pravachol (pravastatin), Mevacor (lovastatin) and Crestor (rosuvastatin) are commonly used in diabetic patients. Unfortunately, these drugs not only reduce cholesterol level, but also may reduce CoQ10 level in the muscles as was demonstrated in a recent study from investigators at Columbia University in the U.S. (6). This phenomenon may explain the muscle aches these patients often experience while on a statin drug. Co Q10 may help to prevent these muscle aches and pains*.
Selenium, Zinc and Magnesium have all been shown to promote healthy glucose levels*.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Serving Size: 2 Tablets
Servings per container: 30 Amount Per Serving
|Ingredient||Amount||% Daily Value|
|Vitamin A||5000 I.U.||100%|
|Vitamin C||100 mg||183% Vitamin E|
|Vitamin E||40 I.U.||132%|
|Folic acid||800 mcg||200%|
|Pantothenic acid||10 mg||100%|
|Magnesium Oxide||200 mg||50%|
|Chromium (as Chromium picolinate)||800mcg||667%|
|* Alpha Lipoic Acid||600 mg|
|*Coenzyme Q 10||50 mg|
|*Cinnamon bark powder||250 mg|
*Daily Value not established.
1. Evans JL, Goldfine ID. Alpha-lipoic acid : a multifunctional antioxidant that improves insulin sensitivity in patients with type 2 diabetes. Diabetes Technol Ther 2000; 2: 401-413.
2. Konrad T, Vicini P, Kusterer K et al. Alpha-Lipioc acid treatment decreases serum lactate and pyruvate concentrations and improves glucose effectiveness in lean and obese patients with type 2 diabetes. Diabetes Care 1999;22:280-287.
3. Ziegler D, Reljanovic M, Mehnert H, Gries FA. Alpha-lipoic acid in the treatment of diabetic polyneuropathy in Germany: current evidence from clinical trials. Exp Clin Endocrinol Diabetes 1999;107:421-430.
4. Anderson R, Cheng N, bryden N, Polansky M, Cheng N, Chi J, Feng J. Elevated Intakes of supplemental chromium improves glucose and insulin variables in individuals with type 2 diabetes. Diabetes 1997;46:1786-1791.
5. Khan A, Safdar M, Khan M, Khan N, Anderson R. Cinnamon improves glucose and lipids of people with type 2 diabetes. Diabetes Care 2003;
6. Rundek T, Naini A, Sacco R, Coates K, DiMauro S. Atorvastatin decreases the coenzyme Q10 level in the blood of patients at risk for cardiovascular disease and stroke. Arch Neurol. 2004;61:889-892.
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This article was written by Sarfraz Zaidi, MD, FACE. Dr. Zaidi specializes in Diabetes, Endocrinology and Metabolism.
Dr. Zaidi is a former assistant Clinical Professor of Medicine at UCLA and Director of the Jamila Diabetes and Endocrine Medical Center in Thousand Oaks, California.
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